Kurzbeschreibung

Significant sex differences exist in the incidence, pathogenesis, pharmacology, and outcome of cardiovascular diseases. The underlying causes are only partially understood. Little is known regarding sex disparities in the vasculature. In a joint cooperation with the group of Prof. Petra Knaus (FU Berlin) strong differences in migration patterns between male and female human endothelial cells were observed. Female human umbilical vein endothelial cells (HUVEC) exhibited significantly increased VEGF-dependent migration compared to male HUVEC. This could suggest differences in vascular repair properties between genders. The aim of our project is therefore to analyze molecular mechanisms for the observed sex differences in migratory properties of male and female HUVEC. In particular, we will focus on sex-specific differences in VEGF- induced signaling pathways of the cells. The results of the project could contribute to our understanding of physiological differences and help to disclose mechanisms responsible for gender differences in the vascular system.

Projektdetails

Projektart

Forschungsprojekt

Fachgruppe

MINT

Fachliche Zuordnung

Chemie

Beginn

9/1/2014

Ende

12/31/2015

Finanzierung

Max-Delbrück-Zentrum für Molekulare Medizin

Einrichtung

Fachbereich/Zentralinstitut

Biologie, Chemie, Pharmazie

Institut/Seminar

Institut für Chemie und Biochemie

Fachgebiet/Arbeitsbereich

Biochemie

Projektteam

Leitung

Univ.-Prof. Dr. Petra Knaus

Schlagwörter

Geschlecht; Geschlechterforschung; Herz- und Kreislaufkrankheit; Humanmedizin; Vaskuläre Krankheiten; Zelle