Description

Significant sex differences exist in the incidence, pathogenesis, pharmacology, and outcome of cardiovascular diseases. The underlying causes are only partially understood. Little is known regarding sex disparities in the vasculature. In a joint cooperation with the group of Prof. Petra Knaus (FU Berlin) strong differences in migration patterns between male and female human endothelial cells were observed. Female human umbilical vein endothelial cells (HUVEC) exhibited significantly increased VEGF-dependent migration compared to male HUVEC. This could suggest differences in vascular repair properties between genders. The aim of our project is therefore to analyze molecular mechanisms for the observed sex differences in migratory properties of male and female HUVEC. In particular, we will focus on sex-specific differences in VEGF- induced signaling pathways of the cells. The results of the project could contribute to our understanding of physiological differences and help to disclose mechanisms responsible for gender differences in the vascular system.

Project Details

Project Type

Research Project

Subject Group

STEM

Subject Classification

Chemistry

Start

9/1/2014

End

12/31/2015

Funding

Max-Delbrück-Zentrum für Molekulare Medizin

Organization

Faculty/Central Institute

Biology, Chemistry, Pharmacy

Institute/Seminar

Institute of Chemistry and Biochemistry

Field/Work Area

Biochemistry

Project Team

Director

Univ.-Prof. Dr. Petra Knaus

Keywords

Cardiovascular Disease; Cell; Gender; Gender Studies; Human Medicine; Vascular Diseases